Propanidid, an intravenous anesthetic agent.
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Formulation and evaluation of a propanidid hydroxypropyl-b-cyclodextrin solution for intravenous anaesthesia
Propanidid is a short acting anaesthetic with poor solubility in water. It was formerly marketed for clinical use as an intravenous (i.v.) anaesthetic in Cremophor EL (Epontol, propanidid 50 mg ml) but this was withdrawn due to anaphylactoid reactions to the vehicle. This paper reports on an aqueous formulation using hydroxypropyl-b-cyclodextrin (HP-b-CD) as a solubiliser. Phase solubility anal...
متن کاملSensitivity to intravenous anaesthetics: a report of three cases.
Three patients with sensitivity to an intravenous anaesthetic-thiopentone, propanidid, and Althesin (alphadolone and alphaxalone)-are described. In the cases of thiopentone and Althesin the reaction was characterized by cardiovascular collapse, while bronchospasm also occurred with thiopentone. The reaction to propanidid was a direct skin sensitivity. All patients had a personal or family histo...
متن کاملA clinical comparison of propanidid and thiopentone as induction agents to general anaesthesia.
Two hundred patients undergoing cystoscopy, with or without retrograde pyelogram, were studied. Half of the patients received 2.5 per cent thiopentone as an induction agent, the remainder received 5 per cent propanidid. On arrival in the operating room, the patients were given atropine 0.4 mg. intravenously. No other premedicant drugs were administered, nor were the patients receiving medicatio...
متن کاملThe effect of thiamylal and propanidid on the isolated heart muscle in comparison with CT 1341.
IWATSUKI, N. The Effect of Thiamylal and Propanidid on the Isolated Heart Muscle in Comparison with CT 1341. Tohoku J. exp. Med ., 1973, 110 (1), 3340 Inotropic effects of thiamylal and propanidid on the contractile state of the isolated dog heart muscle were determined by means of force-velocity relations and compared with those of CT 1341, a new steroid anesthetic. All anesthetics studied pro...
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to intravenous practolol, but this failed during an admission in November 1974. She reverted to sinus rhythm soon after receiving 400 mg propanidid. In March 1975 she was readmitted with a similar tachycardia. Five minutes after receiving 500 mg propanidid she again reverted to sinus rhythm. Case 3.-A 22-year-old woman with Fallot's tetralogy, reconstructed seven years earlier, developed a vent...
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عنوان ژورنال:
- AANA journal
دوره 51 1 شماره
صفحات -
تاریخ انتشار 1983